Chemie Online Titelbild
Buchtipp
Visual C#.NET
W. Doberenz, T. Kowalski
49.90 €

240_cover_small.gif
news
Anzeige

PDF-Download PDF-Download - Seite empfehlen Seite empfehlen - Seite drucken Seite drucken - RSS-Feed

The Nobel Prize in Physiology or Medicine 2006

04.10.2006 - The Nobel Assembly at Karolinska Institutet has decided to award The Nobel Prize in Physiology or Medicine for 2006 jointly to Andrew Z. Fire and Craig C. Mello for their discovery of "RNA interference - gene silencing by double-stranded RNA"

Anzeige


Andrew Z. Fire
Großbildansicht
Bild: Stanford
Abb. 1: Andrew Z. Fire
This year's Nobel Laureates have discovered a fundamental mechanism for controlling the flow of genetic information. Our genome operates by sending instructions for the manufacture of proteins from DNA in the nucleus of the cell to the protein synthesizing machinery in the cytoplasm. These instructions are conveyed by messenger RNA (mRNA). In 1998, the American scientists Andrew Fire and Craig Mello published their discovery of a mechanism that can degrade mRNA from a specific gene. This mechanism, RNA interference, is activated when RNA molecules occur as double-stranded pairs in the cell. Double-stranded RNA activates biochemical machinery which degrades those mRNA molecules that carry a genetic code identical to that of the double-stranded RNA. When such mRNA molecules disappear, the corresponding gene is silenced and no protein of the encoded type is made.

Craig C. Mello
Großbildansicht
Bild: UMASS
Abb. 2: Craig C. Mello
RNA interference occurs in plants, animals, and humans. It is of great importance for the regulation of gene expression, participates in defense against viral infections, and keeps jumping genes under control. RNA interference is already being widely used in basic science as a method to study the function of genes and it may lead to novel therapies in the future.

Quelle: Schwedischer Forschungsrat - The Swedish Research Council

Verwandte News

06.10.2010 The Nobel Prize in Chemistry 2010
05.10.2010 The Nobel Prize in Physics 2010
07.10.2009 The Nobel Prize in Chemistry 2009
08.10.2008 The Nobel Prize in Chemistry 2008
07.10.2008 The Nobel Prize in Physics 2008
10.10.2007 Der Nobelpreis für Chemie 2007
09.10.2007 Der Nobelpreis für Physik 2007
04.10.2006 The Nobel Prize in Chemistry 2006
04.10.2006 The Nobel Prize in Physics 2006
05.10.2005 The Nobel Prize in Chemistry 2005
06.10.2004 The Nobel Prize in Chemistry 2004
05.10.2004 The 2004 Nobel Prize in Physics
05.10.2004 The 2004 Nobel Prize in Physiology or Medicine